HPD: Population Health and Clinical Outcomes Research

HPD 519: Sytematic Review of the Literature

This introductory course will provide students with an understanding of the process used to perform systematic review, as well as provide a "hands on" experience. Each student will perform a systematic review of the literature for their own pre-defined research question of interest. As part of the systematic literature review process, students will learn how to focus their research question; to search the literature to identify relevant studies; to appraise the quality and select studies; and to summarize studies as well as to synthesize their results in context of their original research question raised. To receive a grade for this course, moreover, a scholarly product (e.g., manuscript or letter to the editor) must be submitted to a peer -reviewed journal.


Fall, 3 credits, Letter graded (A, A-, B+, etc.)

HPD 521: Introduction to Clinical Research

This seminar series course provides a broad-based introduction to the fields of population healthand clinical science research. This course will prepare participants to become critical consumers of the peer-reviewed literature. Class lectures will cover a wide range of topics, which include: framing a research question, formulating a research hypothesis, evaluating the peer-reviewed literature, exploring study design options, conducting human subjects' research ethically/responsibly, selecting clinical outcomes, and evaluating analytical alternatives.

Offered in

Summer, 1 credit, Letter graded (A, A-, B+, etc.)

HPD 566: Clinical Trials

This course introduces the design, conduct, and analysis of clinical trials. Topics include types of clinical trials, study design, treatment allocation, randomization and stratification, quality control, sample size requirements, patient consent, and interpretation of results. This course is intended for doctoral level students. (Co-scheduled with HPH 566 Clinical Trials).


Spring, 2 credits, Letter graded (A, A-, B+, etc.)

HPD 567: Clinical Outcomes Research

This course will provide an overview of the field of clinical outcomes assessment. The specific topics covered include: risk factors identification, clinical outcomes selection, risk adjustment methods, patient safety monitoring, and provider-based quality improvement performance reporting. Students will be introduced to a broad range of clinical outcomes including (but not limited to) short term mortality, treatment-related morbidity, health related quality of life, condition specific metrics, patient satisfaction, health plan member satisfaction, utility theory, and cost effectiveness analysis. An emphasis will be placed in this course on learning how clinical outcomes research can provide data-driven approach to influence patient, provided, program, and policy decisions.

Offered Summer/

Fall, 3 credits, Letter graded (A, A-, B+, etc.)

HPD 592: Applied Data Management Using SAS

This course provides students with an introduction to the principles of public health and clinical research-related informatics and data management using the SAS systems. Lectures and labs will be aimed at developing hands-on skills about how to create, maintain, and manage databases using the SAS Systems for Windows, a major software package used frequently in public health and clinical outcomes research.

1 credit, Letter graded (A, A-, B+, etc.)

HPD 601: Human Subjects: Ethics and Responsible Conduct of Research

This introductory course incorporates three components focused upon identifying: 1) the ethical principles associated with human subjects� research; 2) the primary tenets of responsible conduct of research; 3) academic career planning. This course provides a philosophical basis for current research ethics practices, identifies outstanding ethical issues and controversies in clinical and translational science and research, and provides students with knowledge and access to resources such that they may to address the ethical challenges that may arise most effectively. The course provides a more in-depth exploration of the ethics and responsible conduct of clinical and translational science research that can supplement current mandated training in the area.

1 credit, Letter graded (A, A-, B+, etc.)

HPD 619: Independent Study

Intensive reading under supervision of one or more instructors, of material not covered in the formal curriculum, or execution of a research project under the supervision of one or more faculty members. Generally a written deliverable (e.g. manuscript) will be required. Instructor consent required.

0-6 credits, Letter graded (A, A-, B+, etc.)

May be repeated for credit.

HPD 650: Seminar Series: Clinical Applications of Molecular Medicine

This course will provide an overview of the field of molecular medicine, with a focus on cutting edge technologies related to the current and future clinical applications to improve early detection, to enhance diagnostic testing, to monitor treatments, and to counsel patients on their prognosis. As applied to clinical patient care questions, the specific molecular medicine topics discussed will include: DNA, RNA, proteomics, and chromosome assays. Pending the specific lecturers and topics coordinated, students will be introduced to a broad range of biomarkers for disease such as cancer, pulmonary/heart diseases, autism, and immune-related disease challenges. An emphasis will be placed in this course on learning how molecular markers can be applied in a clinical setting to augment the patient and provider decision-making process. (NOTE: Students should have an introductory knowledge of cellular and molecular development biology, as well as a general laboratory background).

Offered in

Spring, 1 credit, Letter graded (A, A-, B+, etc.)

HPD 681: Advanced Social Determinants of Health

This course will build on the prior HPH 523 and further examine the current evidence supporting an association between social deterinants (e.g., socioeconomic status, physical living conditions, individual characteristics, social support, etc) and health. Students will review and critically examine the current literature on the social determinants of population health with the goal of identifying gaps in this literature which may be filled by future research. Concepts relating to the social determinants of health - e.g., identification of current priority areas, theoretical frameworks and perspectives, intervention, research methodology, etc, will be addressed as each comes up in the context of the reviewed jornal article. Using publicly available data sets, students will choose a research topic related to an identified gap in the current research on the social determinants of health, propose a project to examine this topic or need which can be accomplished using publicly available data sets, conduct the analysis and write up their project in a format suitable for submission for publication.


Spring, 3 credits, Letter graded (A, A-, B+, etc.)

HPD 682: Statistical Methods in Clinical Outcomes Research

The purpose of the course is to familiarize students with some major topics in clinical outcomes research, the statistical models commonly employed, and statistical problems that need to be overcome. Specific topics of interest may include: risk factor analysis�static models; risk factor/disease progression analysis�dynamic models; survival analysis (including multivariable survival analysis); volume-outcomes research; and forecasting models. Statistical techniques and challenges will be discussed within the context of each research topic as they arise. By the end of this course, students should be broadly familiar with these issues, and should be able to evaluate published clinical outcomes research in terms of the appropriateness of models chosen and how well the statistical problems have been addresses, and the reliability of the results. Prerequisites: HPH 507 Biostatistics II or equivalent course.


Fall, 3 credits, Letter graded (A, A-, B+, etc.)

HPD 686: Mentored Research Project in Population Health and Clinical Outcomes Research

This course will expose doctoral students to a project with which they are not currently familiar in the field of population health or clinical science. Each student will select a faculty mentor for their course project. Students will identify (with the pre-approval of their mentor and course director) a specific problem to address and/or a component of the mentor's project to complete. Following IRB approval or waiver (if applicable), the mentored project will be initiated. Final grade will be based upon the research proposal, project plan, and final project report submitted.

3 credits, Letter graded (A, A-, B+, etc.)

HPD 693: Practicum in Teaching

The course is a supervised teaching experience with the Master of Public Health program.

Fall, 3 credits, S/U grading

HPD 694: Graduate Seminar in Research Writing

The course will provide mentored writing for dissertation and scientific publications.

Fall, 1-3 credits, Letter graded (A, A-, B+, etc.)

May be repeated for credit.

HPD 699: Dissertation Research On Campus

This course is normally taken by advanced PhD students when they conduct research towards their theses. Only PhD students who have been advanced to candidacy (G5 status) can take this course. Students who have the G3 and G4 status and participate in a research project with their advisor can register for HPD 619 Independent Study.

Prerequisite: Must be advanced to candidacy (G5); permission of instructor

Summer, 0-9 credits, S/U grading

May be repeated for credit.